HNP1
HNP1 (human neutrophil peptide 1) is an alpha-defensin antimicrobial peptide produced by neutrophils and studied for membrane-active antibacterial effects and synergy with other innate peptides.
Tag
Infectious disease
Pages related to Infectious disease.
LL-37
LL-37 (cathelicidin) is a human antimicrobial peptide involved in innate immune defense and widely studied for membrane-active antibacterial and immunomodulatory effects.
Dermcidin
Dermcidin is a human antimicrobial peptide found in sweat and other tissues. A 2026 study reported antiviral activity against influenza via binding hemagglutinin, with mouse protection data.
Lachnospirin-1
A novel antimicrobial peptide reported in 2026 to have activity against carbapenem-resistant Acinetobacter baumannii in vitro and in mouse infection models.
A new trick for shorter LL-37 antibiotics
A preprint suggests a simple chemical add-on can make a short LL-37 fragment more bacteria-killing, hinting at a reusable design rule for antimicrobial peptides.
Two immune peptides team up against bacteria
A new mechanistic study suggests LL-37 and HNP1 can form reversible aggregates that become more active on bacterial-like membranes while staying less toxic to human cells.
Antibody-inspired bicyclic peptides target the conserved influenza HA stem
A 2026 PNAS paper reports constrained bicyclic peptides, inspired by the FI6v3 antibody HCDR3, that bind the conserved hemagglutinin stem and neutralize multiple influenza A subtypes in vitro.
A human skin peptide that blocks influenza
A PNAS study reports that dermcidin, an antimicrobial peptide found in sweat, can bind influenza hemagglutinin, inhibit infection in vitro, and protect mice, with higher levels seen in asymptomatic humans.
Why CRAB still needs new antibiotics: lachnospirin‑1 as an early lead
A 2026 *Virulence* paper reports that lachnospirin‑1 killed carbapenem-resistant *A. baumannii*, disrupted biofilms and persisters, and showed efficacy in mouse infection models. It is still preclinical, but it has the kind of signal package that can justify deeper development.