Peptide gels that act like depots
Peptide drugs fail for a boring reason: delivery. Self-assembling peptide hydrogels try to fix that by turning peptides into local depots that hold and release medicine over time.
Tag
drug-delivery
Peptides often fail for a boring reason: delivery. This tag tracks delivery ideas like depots, conjugates, and designs that change where a peptide goes and how long it lasts.
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A virus-mimicking peptide that pushes mRNA beyond the liver
Researchers describe an enveloped virus-mimicking particle built from a simplified peptide plus tuned lipids, aiming for repeatable mRNA delivery to extrahepatic tissues like lung and spleen.
Donkey-milk exosomes for oral octreotide
A new mouse study tests an exosome-based ‘biomimetic’ delivery idea for oral octreotide, hinting at a path beyond permeability enhancers but leaving big manufacturing and translation questions.
AMG 133 and the antibody-peptide obesity strategy
Researchers describe AMG 133, an antibody-peptide conjugate designed to combine GIP receptor antagonism with GLP-1 receptor agonism. It’s a design story about longer-acting multi-target biology, not a new approved therapy.
A peptide gel to help bladder cancer immunotherapy
A mouse study reports an enzyme-responsive peptide that forms a bladder-local hydrogel depot to retain BCG longer, aiming to reduce washout and improve immune activation in non-muscle-invasive bladder cancer.
A new AI model for finding BBB-crossing peptides
A 2026 Advanced Science paper introduces INB3P, a machine-learning framework built for small peptide datasets. It predicts blood-brain barrier-penetrating motifs and offers interpretability tools, but still needs prospective validation.
A new trick for peptides to enter cells
Researchers report benzaldehyde-tagged cell-penetrating peptides can anchor to membrane proteins via reversible imine chemistry, helping cargo escape endosomes and reach the cytosol.