CYP9
A cyclic peptide engineered from an antimicrobial peptide scaffold (YD) that showed preclinical anti-fibrotic activity by suppressing TGF-β/Smad and MAPK pathway signaling in experimental models.
Tag
Pulmonary
Pages related to Pulmonary.
Tag
Pages related to Pulmonary.
A cyclic peptide engineered from an antimicrobial peptide scaffold (YD) that showed preclinical anti-fibrotic activity by suppressing TGF-β/Smad and MAPK pathway signaling in experimental models.
Researchers took an antimicrobial peptide, tightened it into a drug-like cyclic version (CYP9), and reported reduced lung-fibrosis signaling in preclinical models. Early, but a useful example of peptide engineering.