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Pages related to Oral health.
A mouse study engineers a sublingual nanovaccine that combines a gingipain antigenic peptide with CpG adjuvant inside a tetrahedral DNA scaffold and hydrogel, boosting salivary IgA and reducing periodontitis signs.
An NPJ Biofilms & Microbiomes paper reports that a Streptococcus salivarius strain (SALI-10) produces phosphorylated lantibiotics (pLANs), can engraft into dysbiotic human-derived oral biofilms, suppress periopathogens, and shows a small first-in-human feasibility signal after 1 week of daily dosing. It’s early, but it’s a concrete example of peptide-like natural products paired with a ‘live’ delivery vehicle.