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Pages related to Macrocycles.
A Nature Communications paper introduces CycloSEL, a mass spectrometry driven workflow that screens fully synthetic macrocycle libraries and reports an intracellular-target hit later optimized for permeability.
A Journal of Medicinal Chemistry study uses yeast display to screen millions of disulfide-cyclized peptides and turns up low‑nanomolar inhibitors of human ACE2, backed by crystal structures.
A 2026 PNAS paper reports a way to co-opt bacterial lipoprotein processing to biosynthesize lipidated macrocyclic peptides. It is a methods advance that could matter for lipopeptide discovery and tuning pharmacology.
A medicinal-chemistry study suggests one residue, Aib, can sometimes ‘pre-organize’ macrocyclic peptides so they cross membranes more easily, improving oral exposure in mice. It is scaffold-dependent, not magic.