The next oral peptide story is an immune drug
Icotrokinra, the FDA-approved oral peptide IL-23 receptor antagonist for plaque psoriasis, shows how peptide pills are moving from metabolic medicine into immunology.
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Immunology
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Cancer vaccines are becoming a peptide delivery problem
A phase 1 KRAS peptide vaccine study shows why the next cancer-vaccine story may be less about picking an antigen and more about getting peptide signals to the right immune neighborhood.
A beta cell-targeted PD‑1 agonist for type 1 diabetes
A Science Advances paper describes a bispecific ‘ImmTAAI’ molecule that binds a preproinsulin peptide–HLA complex on beta cells and delivers a PD‑1 agonist signal to suppress autoreactive T cells locally in human pancreas slice models. It’s early, but it’s an unusually concrete example of tissue-targeted immunomodulation in type 1 diabetes.