HNP1
HNP1 (human neutrophil peptide 1) is an alpha-defensin antimicrobial peptide produced by neutrophils and studied for membrane-active antibacterial effects and synergy with other innate peptides.
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Pages related to Immune.
HNP1 (human neutrophil peptide 1) is an alpha-defensin antimicrobial peptide produced by neutrophils and studied for membrane-active antibacterial effects and synergy with other innate peptides.
LL-37 (cathelicidin) is a human antimicrobial peptide involved in innate immune defense and widely studied for membrane-active antibacterial and immunomodulatory effects.
Vasoactive intestinal peptide (VIP) is an endogenous neuropeptide hormone involved in vasodilation, smooth muscle relaxation, and immune signaling. A 2026 preclinical paper reported VIP-induced autophagy and cytotoxicity in renal cell carcinoma models via a proposed SIRT3-dependent pathway.
Dermcidin is a human antimicrobial peptide found in sweat and other tissues. A 2026 study reported antiviral activity against influenza via binding hemagglutinin, with mouse protection data.
An immune-modulating peptide (thymalfasin) studied across infectious and immune contexts.
A new mechanistic study suggests LL-37 and HNP1 can form reversible aggregates that become more active on bacterial-like membranes while staying less toxic to human cells.
A PNAS study reports that dermcidin, an antimicrobial peptide found in sweat, can bind influenza hemagglutinin, inhibit infection in vitro, and protect mice, with higher levels seen in asymptomatic humans.