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Pages related to Cyclic peptides.
A 2026 paper retrains an all-atom diffusion model to generate accurate conformers for small cyclic peptides, including noncanonical amino acids and complex linkages, with a practical stereochemistry correction step.
Researchers report a bicyclic peptide isomer (10‑Mansa) that selectively inhibits integrin αvβ6 and shows prolonged tumor enrichment in preclinical work, highlighting how 3D peptide shape can make or break targeting.
Researchers took an antimicrobial peptide, tightened it into a drug-like cyclic version (CYP9), and reported reduced lung-fibrosis signaling in preclinical models. Early, but a useful example of peptide engineering.